| Bioactivity | (+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons[1]. |
| Target | nAChR |
| Invitro | (+)-Sparteine (2 μM) (sulfate pentahydrate) reduces the ACh-induced current caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials of -50 mV to +30 mV, whereas its blocking effect increased at more negative membrane potentials. (+)-sparteine (5 μM and 10 μM) (sulfate pentahydrate) reduces the amplitude of the excitatory postsynaptic currents (EPSC) and the time constant of the EPSC decay[1]. |
| Name | (+)-Sparteine sulfate pentahydrate |
| Formula | C15H38N2O9S |
| Molar Mass | 422.54 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. |
(+)-Sparteine sulfate pentahydrate
CAS: F: C15H38N2O9S W: 422.54
(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent.(+)-Sparteine competitively blocks nicotinic ACh rec
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