| Bioactivity | MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R[1][2]. | ||||||||||||
| Target | IC50 : 5 nM (AA3R) | ||||||||||||
| Invitro | MRE3008F20 (0.1-100 nM) antagonizes 100 nM Cl-IB-MECA-induced inhibition of cAMP levels in resting human lymphocytes[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | MRE3008F20 | ||||||||||||
| CAS | 252979-43-4 | ||||||||||||
| Formula | C21H20N8O3 | ||||||||||||
| Molar Mass | 432.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gessi S, et al. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol. 2004 Mar;65(3):711-9. [2]. Baraldi P G, et al. New potent and selective human adenosine A3 receptor antagonists. Trends in pharmacological sciences, 2000, 21(12): 456-459. |
MRE3008F20
CAS: 252979-43-4 F: C21H20N8O3 W: 432.44
MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM).
Data collection：peptidedb@qq.com
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