MR2938_product_DataBase

Bioactivity	MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1].
Invitro	MR2938 (0-10 μM, 24 h) 在 1.25 μM 时降低促炎细胞因子 IL-1β、TNF-α、IL-6 和 CCL2 的 mRNA 水平[1]。MR2938 (10 μM, 24 h) 阻断 LPS 诱导的 BV-2 细胞中的 NF-κB 信号通路[1]。MR2938 (20 μM) 对 AChE 和 BChE 具有抑制活性，抑制率分别为 91.8 ± 2.68% 和 38.7 ± 11.7%[1]。MR2938 (0-10 μM) 对 BV2 细胞系的细胞活力影响很小[1]。 RT-PCR[1] Cell Line:
Name	MR2938
CAS	1044870-65-6
Formula	C21H24N4O3
Molar Mass	380.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lv L, et al. Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities. Eur J Med Chem. 2023 Apr 6;254:115346.

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