Influenza virus-IN-4_product_DataBase

Bioactivity	Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1].
Target	IC50: 3.4 µM (H5N1); 0.094 µM (H5N2); 0.79 µM (H5N6); 0.077 µM (H5N8)
Invitro	Influenza virus-IN-4 (compound 11e) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 33.26, 16.81, 45.46, 33.02, 5270.33, 0.00043, 0.00347 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].
Name	Influenza virus-IN-4
CAS	2133818-85-4
Formula	C23H31FN2O4
Molar Mass	418.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ai W, et al. Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors. Eur J Med Chem. 2020 Apr 1;191:112147.

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