| Bioactivity | MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 selectively target MST3/4, with EC50 values of 57 and 583 nM, respectively[1]. |
| Target | IC50: 57 ± 44 nM (MST3), 583 ± 210 nM (MST4) |
| Invitro | MR24 (10 μM, 24-72 h) 导致细胞周期停滞在 G1 期[1]。MR24 在 1 小时内表现出超过 90% 的优异微粒体稳定性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MR24 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| Formula | C26H29ClN6O3 |
| Molar Mass | 509.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Marcel Rak, et al. Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J. Med. Chem. 2024. |