| Bioactivity | MOR agonist-4 (2d) is a G protein signaling-biased Kappa opioid receptor (KOR) agonist with an EC50 value of 11 nM. MOR agonist-4 contains an electron withdrawing CF3 group and a bias factor of 38 based on triazole. MOR agonist-4 is used in the research of pruritis and analgesia[1]. |
| Invitro | MOR agonist-4 (10 μM) 完全抑制了 KOR 与合适的放射性标记受体配体 U69,593 的结合，其 Ki 值为 5.8 nM，但配体与 MOR 和 DOR 的结合较差 (分别为 30.9% 和 30.7%)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MOR agonist-4 相关抗体: |
| Formula | C22H19F3N4S |
| Molar Mass | 428.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Trojniak AE, et al. Synthesis and evaluation of 3,4,5-trisubstituted triazoles as G protein-biased kappa opioid receptor agonists[J]. Eur J Med Chem. 2024 Jun 27;276:116627. |