| Bioactivity | MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling[1]. |
| Invitro | MLS1082 potentiate β-Arrestin- and G protein-Mediated D1R signaling[1]. |
| Name | MLS1082 |
| CAS | 883958-36-9 |
| Formula | C24H23N3O2 |
| Molar Mass | 385.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696. [2]. Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209. |