| Bioactivity | α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer’s disease[1]. |
| Name | α-Conotoxin PnIA |
| CAS | 705300-84-1 |
| Sequence | Gly-Cys-Cys-Ser-Leu-Pro-Pro-Cys-Ala-Ala-Asn-Asn-Pro-Asp-Tyr-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16) |
| Shortening | GCCSLPPCAANNPDYC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16) |
| Formula | C65H95N19O22S4 |
| Molar Mass | 1622.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gene Hopping, et al. Hydrophobic Residues at Position 10 of α-conotoxin PnIA Influence Subtype Selectivity Between α7 and α3β2 Neuronal Nicotinic Acetylcholine Receptors. Biochem Pharmacol. 2014 Oct 15;91(4):534-42. |
α-Conotoxin PnIA
CAS: 705300-84-1 F: C65H95N19O22S4 W: 1622.80
α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of n
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