| Bioactivity | ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a drug blocker[1]. | ||||||||||||
| Invitro | ML353 是一种充分可溶性化合物，在 PBS 中的溶解度为 16.9 µM 或 6.0 µg/mL (PH=7.4)[1]。ML353 在 PBS 缓冲液中具有优异的稳定性[1]。 | ||||||||||||
| Name | ML353 | ||||||||||||
| Formula | C19H15FN2O | ||||||||||||
| Molar Mass | 306.33 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gregory KJ, et al. Identification of a high affinity MPEP-site silent allosteric modulator (SAM) for the metabotropic glutamate subtype 5 receptor (mGlu5). 2013 Apr 15 [updated 2015 Feb 11]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. |