| Bioactivity | ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM)[1]. |
| Target | EC50: 3.7 μM (Apelin receptor) |
| Invitro | ML233 shows potentially significant binding against several other receptors, including the 5-HT1A, α2C adrenergic, and benzylpiperazine receptors and norepinephrine transporter. ML233 shows some toxicity (LC50=25.8 μM) toward human hepatocyctes[1]. |
| Name | ML233 |
| CAS | 2080311-92-6 |
| Formula | C19H21NO4S |
| Molar Mass | 359.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Khan P. National Center for Biotechnology Information; 2011. Functional agonists of the apelin (APJ) receptor. In Probe Reports from the NIH Molecular Libraries Program. |