| Bioactivity | Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3]. |
| Target | K(ATP) channel |
| Invitro | Glisoxepide inhibits the uptake of bile acids into isolated rat hepatocytes[3].Glisoxepide noncompetitively inhibits the cholate uptake with a Ki of 200 μM[3]. |
| Name | Glisoxepide |
| CAS | 25046-79-1 |
| Formula | C20H27N5O5S |
| Molar Mass | 449.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sato T, et al. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316(1):182-8. Epub 2005 Sep 20. [2]. Selvaag E. Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Aug;12(4):166-70. [3]. Fückel D, et al. Interaction of sulfonylureas with the transport of bile acids into hepatocytes. Eur J Pharmacol. 1992 Mar 31;213(3):393-404. |
Glisoxepide
CAS: 25046-79-1 F: C20H27N5O5S W: 449.52
Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycem
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