| Bioactivity | MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1]. |
| In Vivo | MK-8189 (0.25-0.75 mg/kg; po) 以剂量依赖的方式减弱大鼠的运动活动。 Animal Model: |
| Name | MK-8189 |
| CAS | 1424371-93-6 |
| Formula | C19H22N6OS |
| Molar Mass | 382.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66(2):1157-1171. |