| Bioactivity | (Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration[1]. | ||||||||||||
| Target | IC50: 1.8 μM (M5) | ||||||||||||
| Name | (Rac)-VU 6008667 | ||||||||||||
| CAS | 2092917-63-8 | ||||||||||||
| Formula | C24H17ClF2N2O2 | ||||||||||||
| Molar Mass | 438.85 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. |
(Rac)-VU 6008667
CAS: 2092917-63-8 F: C24H17ClF2N2O2 W: 438.85
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (I
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