Bioactivity | MI-219 is an antagonist for MDM2 with a Ki of 13.3 μM. MI-219 inhibits the MDM2-p53 interaction, inhibits thus the proliferation of FSCCL cells, with an IC50 of 2.5 μM[1]. |
CAS | 908027-55-4 |
Formula | C27H32Cl2FN3O4 |
Molar Mass | 552.47 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Mohammad RM, et al., An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals. Mol Cancer. 2009 Dec 3;8:115. |