Anti-inflammatory agent 86

CAS: F: C29H34N2O5S2 W: 554.72

Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86

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Bioactivity	Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research[1].
Invitro	Anti-inflammatory agent 86（化合物4b）对 TNF-α 诱导的单核细胞粘附 HT-29 细胞表现出显著的抑制活性，IC50 值为 4.71 μM[1]。Anti-inflammatory agent 86（5-10 μM；4小时）以浓度依赖性方式显着抑制 MCP-1 的表达。Anti-inflammatory agent 86 以剂量依赖性方式抑制 HT-29 细胞中的 NF-κB 活性[1]。 Anti-inflammatory agent 86（5-10 μM）对 TNF-α 诱导的 ROS 生成具有显著的抑制作用，且呈剂量依赖性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anti-inflammatory agent 86 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Anti-inflammatory agent 86（30-60 mg/kg；口服；每日一次；连续 15 天）在治疗 TNBS 诱导的结肠炎方面表现出最显著的疗效[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C29H34N2O5S2
Molar Mass	554.72
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pengyu Zhao, et al. Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease. Front Chem. 2024 May 27:12:1406051.