| Bioactivity | MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1]. | ||||||||||||
| Invitro | MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line[1]. | ||||||||||||
| Name | MI-1061 | ||||||||||||
| CAS | 1410737-34-6 | ||||||||||||
| Formula | C30H26Cl2FN3O4 | ||||||||||||
| Molar Mass | 582.45 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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MI-1061
CAS: 1410737-34-6 F: C30H26Cl2FN3O4 W: 582.45
MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0
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