| Bioactivity | MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant[1]. | ||||||||||||
| Name | MGL-IN-1 | ||||||||||||
| CAS | 1881244-28-5 | ||||||||||||
| Formula | C24H22FN5O4 | ||||||||||||
| Molar Mass | 463.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Brindisi M, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 Mar 24;59(6):2612-32. |
MGL-IN-1
CAS: 1881244-28-5 F: C24H22FN5O4 W: 463.46
MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 allevi
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