| Bioactivity | ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. |
| Target | IC50: 8 nM (TPH) |
| Invitro | TPH comprises two isoforms: TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS), while TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets[1]. |
| Name | ACT-678689 |
| CAS | 1783256-96-1 |
| Formula | C23H22ClFN6O4S2 |
| Molar Mass | 565.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Daniel Bur, et al. Tricyclic piperidine compounds. WO2015075023A1. |