| Bioactivity | MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies[1]. |
| Invitro | MEL24 作用于 293T 细胞，ED50 值为 9.2 μM[1]。 MEL24（15 μM，6 小时）增加 Mdm2、p53 和 MdmX 的水平并激活 p53，抑制 HCT116 细胞（p53 野生型）中内源性 MdmX 的降解[1]。 |
| Name | MEL24 |
| CAS | 642072-48-8 |
| Formula | C17H18N4O3 |
| Molar Mass | 326.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ariel G Herman, et al. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011 Sep;1(4):312-25. |