| Bioactivity | Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active[1][2][3]. |
| Invitro | Seselin 对 P-388 和 HT-29 细胞有毒性，ED50 分别为 8.66 和 9.94 μg/mL [1]。Seselin (5-20 μM; 0.5-24 h) 抑制 LPS 和 IFN-γ 刺激的巨噬细胞的细胞因子输出[3]。Seselin (5-20 μM; 12 h) 抑制 BMDMs 中促炎巨噬细胞标志物 (iNOS、phagocytosis、CD11c) 的表达[3]。Seselin (5-20 μM; 0.5-6 h) 阻断 STAT1 信号通路[3]。 RT-PCR[3] Cell Line: |
| In Vivo | Seselin (0.5-40.5 mg/kg; s.c.; once) 在小鼠中显示外周抗炎和抗伤感受活性[2]。Seselin (3-30 mg/kg; i.g.; once) 改善小鼠盲肠结扎和穿刺引起的脓毒症[3]。 Animal Model: |
| Name | Seselin |
| CAS | 523-59-1 |
| Formula | C14H12O3 |
| Molar Mass | 228.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chou HC, et al. Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia. Planta Med. 2005 Nov;71(11):1078-81. [2]. Lima V, et al. Antinociceptive activity of the pyranocoumarin seselin in mice. Fitoterapia. 2006 Dec;77(7-8):574-8.Lima V, et al. Antinociceptive activity of the pyranocoumarin seselin in mice. Fitoterapia. 2006 Dec;77(7-8):574-8.Lima V, et al. Antinociceptive activity of the pyranocoumarin seselin in mice. Fitoterapia. 2006 Dec;77(7-8):574-8. [3]. Feng L, et al. Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages. Br J Pharmacol. 2019 Jan;176(2):317-333. |