| Bioactivity | MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1]. |
| Invitro | MEK-IN-5 (compound 18h) shows anti-proliferation activities for different tumor cells and low toxicity for normal cells[1].MEK-IN-5 (0.1, 1, 10 µM; 1, 2, 4, 6 h) decreases the expression level of pMEK and pERK in a dose-dependent and time-dependent manner[1].MEK-IN-5 (1, 10 µM; 24 h) induces apoptosis in MDA-MB-231 cells[1].MEK-IN-5 (100 µM; 2h) significantly induce NO release in HCT116 cells[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | MEK-IN-5 |
| CAS | 2417022-06-9 |
| Formula | C29H27FN4O10S2 |
| Molar Mass | 674.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
MEK-IN-5
CAS: 2417022-06-9 F: C29H27FN4O10S2 W: 674.67
MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-de
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