| Bioactivity | MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC50 value of 0.3 μM[1]. |
| Target | murine double minute 2 (MDM2); X-linked inhibitor of apoptosis protein (XIAP) |
| Name | MDM2/XIAP-IN-2 |
| CAS | 2761969-85-9 |
| Formula | C29H32N2O4S |
| Molar Mass | 504.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu Z, et al. Discovery of N-(3, 4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2, 3, 3a, 4, 5, 9b-hexahydrofuro [3, 2-c] quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor[J]. Journal of medicinal chemistry, 2021, 64(4): 1930-1950. |
MDM2/XIAP-IN-2
CAS: 2761969-85-9 F: C29H32N2O4S W: 504.64
MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP).
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.