MDM2/XIAP-IN-1_product_DataBase

Bioactivity	MDM2/XIAP-IN-1 (compound 14) is an orally active inhibitor of dual MDM2/XIAP. MDM2/XIAP-IN-1 has anti-cancer activity with an IC50 value of 0.3 μM, which can be used in cance rescrch[1].
Target	IC50:0.3 μM (EU-1 cell)
Invitro	MDM2/XIAP-IN-1 (0-4 μM, 2 weeks) 抑制 EU-1、EU-3 和 NB-1643、SHEP 和 LA1-55 的细胞活性[1]。MDM2/XIAP-IN-1 可降解 MDM2和d XIAP，并靶向杀伤肿瘤细胞，对普通细胞无毒性。 Clonogenic Assay： Cell Line:
In Vivo	MDM2/XIAP-IN-1 Pharmacokinetic Analysis in Male SD rats Model[1]药代动力学分析[1]Route
Name	MDM2/XIAP-IN-1
CAS	359595-95-2
Formula	C28H28N2O4S
Molar Mass	488.60
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhongzhi Wu, et al. Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Med. Chem. 2021, 64, 4.

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