| Bioactivity | MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner[1]. | ||||||||||||
| Invitro | MDK83190 (Compound 2) (1-50 μM; 2 hours) effects against cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) with IC50 values ranging from 4 to 9 μM[1].MDK83190 (Compound 2) (20 μM; 30 mins) activates procaspase-9 and procaspase-3 in a cyto c-dependent manner[1].MDK83190 (Compound 2) (0.1-100 μM; 22 hours) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation, and finally killing cells with an IC50 of 4 μM[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | MDK83190 | ||||||||||||
| CAS | 79183-19-0 | ||||||||||||
| Formula | C15H9Cl2NO2 | ||||||||||||
| Molar Mass | 306.14 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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