| Bioactivity | MDEG-541 is a potent MYC-MAX degrader. MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein[1]. |
| Invitro | MDEG-541 (10 µM; 3, 12, 24 h) 以时间依赖性方式降低 KP4 细胞中 GSPT1、MYC、GSPT2 和 PLK1 蛋白的表达[1]。 Western Blot Analysis[1] Cell Line: |
| Name | MDEG-541 |
| Formula | C35H38N4O7S |
| Molar Mass | 658.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lier S, et al. A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorg Chem. 2022 Feb;119:105505. |