MCT1-IN-3_product_DataBase

Bioactivity	MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer[1].
Target	IC50: 81.0 nM (MCT1)GI50: 20 μM (A-549); 15.1 μM (MCF-7)
Invitro	MCT1-IN-3 (compound 24) 对 MCT1 具有抑制活性，IC50 值为 81.0 nM[1]。MCT1-IN-3 对表达 MCT1 的癌细胞系 A-549 和 MCF-7 具有很强的抗增殖活性，GI50 值分别为 20 μM 和 15.1 μM[1].MCT1-IN-3（5 μM；24 h）导致癌细胞周期停滞和细胞凋亡[1]。MCT1-IN-3（1.0、2.0、3.5 和 5.0 μM）显示可使这些癌细胞对抗肿瘤药物敏感[1]。MCT1-IN-3 还对多药转运蛋白 ABCB1 具有显著的抑制作用，并显示可逆转 ABCB1 介导的多药耐药性 (MDR) [1]。 Cell Cycle Analysis[1] Cell Line:
Name	MCT1-IN-3
CAS	2878360-80-4
Formula	C22H19N3O4
Molar Mass	389.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sachin Puri, et al. Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). J Med Chem. 2023 Jan 12;66(1):657-676.

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