| Bioactivity | CamA-IN-1 is a Clostridioides difficile-specific DNA adenine methyltransferase (CamA) inhibitor. CamA-IN-1 has inhibitory for CamA with IC50 and Kd values of 0.4 μM and 0.2 μM, respectively. CamA-IN-1 can be used for the research of Clostridioides difficile infections (CDI)[1]. | ||||||||||||
| Target | IC50: 0.4 μM (CamA)Kd: 0.2 μM (CamA) | ||||||||||||
| Invitro | CamA-IN-1 (compound 39) 对 CamA 具有抑制作用，IC50 和 Kd 值分别为 0.4 μM 和 0.2 μM[1] .相对于密切相关的细菌和哺乳动物 DNA 和 RNA 转移酶、蛋白质赖氨酸和精氨酸转移酶以及人类腺苷受体，CamA-IN-1 对 CamA 具有选择性[1]。 | ||||||||||||
| Name | CamA-IN-1 | ||||||||||||
| Formula | C23H36N6O6 | ||||||||||||
| Molar Mass | 492.57 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Jujun Zhou, et al. Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence. J Med Chem. 2023 Jan 12;66(1):934-950. |