| Bioactivity | MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1]. |
| Target | IC50: 1.3 μM (Drp1) |
| Invitro | MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1].MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MB-0223 相关抗体: |
| CAS | 2247732-89-2 |
| Formula | C26H27N5OS |
| Molar Mass | 457.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ashley Mallat,et al. Characterization of Small Molecule Inhibitors of Drp1. |