| Bioactivity | AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction[1]. | ||||||||||||
| Target | Kd: 15.4 μM (VDAC1) | ||||||||||||
| Invitro | AKOS-22 (5-20 μM; 2 hours) inhibits both VDAC1 oligomerization and apoptosis in a concentration-dependent manner (IC50=7.5 μM)[1]. AKOS-22 inhibits selenite-induced VDAC1 oligomerization, Cyto c release and apoptosis in HEK-293 cells (IC50=3.3-3.6 μM). AKOS-22 (30 μM, 2 h) inhibits cisplatin-induced VDAC1 oligomerization and apoptosis in neuroblastoma cell line SH-SY5Y. AKOS-22 prevents the elevation of [Ca2+]I associated with apoptosis induction, and thus Ca2+ accumulation by the mitochondria[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AKOS-22 相关抗体: | ||||||||||||
| CAS | 878983-38-1 | ||||||||||||
| Formula | C22H21ClF3N3O3 | ||||||||||||
| Molar Mass | 467.87 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protectagainst Mitochondrial Dysfunction. Biol Chem. 2016 Nov 25;291(48):24986-25003. |
AKOS-22
CAS: 878983-38-1 F: C22H21ClF3N3O3 W: 467.87
AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 int
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