| Bioactivity | MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 significantly inhibits replication of HMPV, AdV and RSV, reduces viral infection-induced cytokine/chemokine production, and inhibits NF-κB activation. MAY0132 has antiviral activity and can be used in the study of respiratory virus infection[1][2]. |
| Target | IC50: 0.4 μM (EPAC2) |
| CAS | 1895861-88-7 |
| Formula | C16H15ClF3N |
| Molar Mass | 313.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Choi EJ, et al. Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections. Viruses. 2021 Jun 21;13(6):1179. [2]. Wild CT, et al. Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors. ACS Med Chem Lett. 2016 Mar 28;7(5):460-4. |