| Bioactivity | MASP-2-IN-1 (Compound 77) is the inhibitor for mannan-binding lectin-associated serine protease (MASP), that inhibits MASP2 and MASP3 with IC50 of 11.4 nM and 13.2 µM. MASP-2-IN-1 exhibits a weak inhibitory activity against hERG with an IC50 of 175 µM. MASP-2-IN-1 reveals a poor stability in mouse plasma with a half-life of 4.4 hours[1]. |
| Formula | C22H21N7O3S |
| Molar Mass | 463.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nakhla M C, et al. Small Molecule Inhibitors of Mannan-Binding Lectin-Associated Serine Proteases-2 and-3[J]. European Journal of Medicinal Chemistry, 2025: 117238. |