| Bioactivity | M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb)[1]. |
| Invitro | M8-B (0-100 µM) 以剂量依赖性方式抑制最大 Ca2+ 摄取来抑制 TRPM8 通道活性[1]。 |
| In Vivo | M8-B (6 mg/kg; i.v. or i.p.) 降低大鼠和小鼠的深部体温[1]。 Animal Model: |
| Name | M8-B |
| CAS | 883976-12-3 |
| Formula | C22H25ClN2O3S |
| Molar Mass | 432.96 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Almeida MC, et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32(6):2086-99. |