| Bioactivity | M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6[1]. |
| In Vivo | M4K2306 (25 mg/kg，口服，单剂量) 在 NOD-SCID 小鼠模型中暴露后 1 小时和 24 小时的血浆浓度 Cmax 分别为 254 和 17 mM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C28H34N4O3 |
| Molar Mass | 474.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. González-Álvarez H, et al., Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67(6):4707-4725. |