Deacylketoconazole

CAS: 67914-61-8 F: C24H26Cl2N4O3 W: 489.39

Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylke

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Bioactivity	Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte[1][2][3].
Invitro	Deacylketoconazole 对 Staphylococcus aureus，Plasmodium falciparum，Candida albicans 和 Candida tropicalis 具有抗真菌和抗菌活性，MIC50 分别为 25 μM，0.4 μg/mL，31 μg/mL 和 62 μg/mL[1][2]。Deacylketoconazole (0-60 μM) 对人肝来源的 HepaRG 细胞具有剂量依赖性的细胞毒性，EC50 为 22.8 μM[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Deacylketoconazole 相关抗体: Cell Cytotoxicity Assay[3] Cell Line:
CAS	67914-61-8
Formula	C24H26Cl2N4O3
Molar Mass	489.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pfaller MA, et al., Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates. Antimicrob Agents Chemother. 1982 Nov;22(5):917-9. [2]. Bossche H V, et al., Molecular basis for the antimycotic and antibacterial activity of N‐substituted imidazoles and triazoles: The inhibition of isoprenoid biosynthesis[J]. Pesticide science, 1984, 15(2): 188-198. [3]. Fukami T, et al., Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity. Biochem Pharmacol. 2016 Sep 15;116:153-61.