| Bioactivity | M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3]. | ||||||
| In Vivo | M40 TFA (0.1-1 nmol，脑室内注射，单剂量) 根据对 N 端甘丙肽受体的识别，选择性阻断 Sprague-Dawley 大鼠模型中甘丙肽-(1-15) 诱导的中枢心血管反应 [1]。M40 TFA (2-8 nmol，脑室或海马体内注射，单剂量) 在 SD 大鼠模型中表现出对甘丙肽诱导的记忆缺陷的拮抗作用，具有减轻与阿尔茨海默病相关的认知缺陷的潜力[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||
| Sequence | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2 | ||||||
| Shortening | GWTLNSAGYLLGPPPALALA-NH2 | ||||||
| Formula | C95H146N22O24.xC2HF3O2 | ||||||
| Molar Mass | 1980.31 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Narváez JA, et al., The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15). Eur J Pharmacol. 2000 Jul 7;399(2-3):197-203. [2]. McDonald MP, et al., Galanin inhibits performance on rodent memory tasks. Ann N Y Acad Sci. 1998 Dec 21;863:305-22. [3]. Branchek T, et al., Molecular biology and pharmacology of galanin receptors. Ann N Y Acad Sci. 1998 Dec 21;863:94-107. |
M40 TFA
CAS: F: C95H146N22O24.xC2HF3O2 W: 1980.31 (free base)
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on differ
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