| Bioactivity | G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (KD = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines[1][2]. |
| Invitro | G7-18NATE (10 μM, 24 h) 抑制 MDA-MB-468 细胞迁移[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> G7-18NATE 相关抗体: |
| CAS | 936728-13-1 |
| Sequence | cyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-) |
| Shortening | cyclo(CH2CO-WFEGYDNTFP-Cys(NH2)-S-) |
| Formula | C67H80N14O19S |
| Molar Mass | 1417.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739. [2]. Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15. |
G7-18NATE
CAS: 936728-13-1 F: C67H80N14O19S W: 1417.50
G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (KD = 18.1 μM
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