| Bioactivity | M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model[1]. |
| Target | M3 mAChR, PDE4 |
| Name | M3/PDE4 modulator-1 |
| Formula | C38H41Cl2N3O8S |
| Molar Mass | 770.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rizzi A, et al. Optimization of M3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. J Med Chem. 2023 Aug 24;66(16):11476-11497.. |
M3/PDE4 modulator-1
CAS: F: C38H41Cl2N3O8S W: 770.72
M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PD
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