| Bioactivity | LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases. The pharmacokinetic properties of LB244 indicate limited oral activity in mice[1]. |
| In Vivo | LB244 (10 mg/kg, po; 5 mg/kg, ip) 在小鼠中的药代动力学结果显示，口服活性有限 (Cmax=0.04 μM)，半衰期较短 (T1/2=2.8 h)。其体内清除率为 2854.3 mL/min/kg[1]。 |
| Name | LB244 |
| Formula | C30H27N5O5 |
| Molar Mass | 537.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Barasa L, et al. Development of LB244, an Irreversible STING Antagonist. J Am Chem Soc. 2023 Sep 20;145(37):20273-20288.. |