Losigamone

CAS: 112856-44-7 F: C12H11ClO4 W: 254.67

Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates t

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Bioactivity	Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research[1][2].
CAS	112856-44-7
Formula	C12H11ClO4
Molar Mass	254.67
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen H, et al. Losigamone add-on therapy for focal epilepsy. Cochrane Database Syst Rev. 2019 Dec 11;12(12):CD009324. [2]. Jones FA, et al. The anticonvulsant effects of the enantiomers of losigamone. Br J Pharmacol. 1999 Nov;128(6):1223-8.

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