| Bioactivity | Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis[1][2][3]. | ||||||||||||
| Invitro | Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells[3].Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation[4].Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion[4].Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities[4].Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells[4]. | ||||||||||||
| Name | Lonidamine | ||||||||||||
| CAS | 50264-69-2 | ||||||||||||
| Formula | C15H10Cl2N2O2 | ||||||||||||
| Molar Mass | 321.16 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Lonidamine
CAS: 50264-69-2 F: C15H10Cl2N2O2 W: 321.16
Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibit
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