| Bioactivity | Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina[1][2][5]. |
| Invitro | Perhexiline (5-25 μM, 2-6 h) maleate reduces cell viability in HepG2 cells[2].Perhexiline (5-25 μM, 2-6 h) maleate reduces cellular ATP content and Lactate dehydrogenase (LDH) release in HepG2 cells[2].Perhexiline (20 μM, 2 h) maleate activates caspase 3/7 in HepG2 cells[2].Perhexiline (5-25 μM, 4 h) maleate causes mitochondrial dysfunction in HepG2 cells[2].Perhexiline (5 μM, 48 h) maleate selectively induces massive apoptosis in CLL cells (high expression of CPT)[3]. Cell Viability Assay[2] Cell Line: |
| Name | Perhexiline maleate |
| CAS | 6724-53-4 |
| Formula | C23H39NO4 |
| Molar Mass | 393.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Perhexiline maleate
CAS: 6724-53-4 F: C23H39NO4 W: 393.56
Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.