Bioactivity | Lipstatin is a very potent pancreatic lipase inhibitor can be isolated from Streptomyces toxytricini. Lipstatin inhibits the hydrolysis of trioleate by porcine pancreatic lipase with an IC50 of 0.14 μM[1]. |
In Vivo | Lipstatin(20、60 mg/kg;口服;单剂量;3 天)剂量依赖性地抑制三油酸甘油酯的吸收,而油酸在小鼠体内吸收正常[1]。 |
Name | Lipstatin |
CAS | 96829-59-3 |
Formula | C29H49NO5 |
Molar Mass | 491.70 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Weibel E K, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini I. Producing organism, fermentation, isolation and biological activity[J]. The Journal of antibiotics, 1987, 40(8): 1081-1085. |