| Bioactivity | Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer[1][2]. |
| Invitro | Leteprinim (5–50 ng/mL，24 和 48 小时) 可增强神经递质释放，增加 PC12 细胞中突触素的分泌[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Leteprinim 相关抗体: |
| In Vivo | AIT-082 (30 或 60 mg/kg，腹膜内注射，持续 7 天) 可保护大鼠免受红藻氨酸 (12 mg/kg) 诱导的海马神经元兴奋性毒性[1]。AIT-082 (60 mg/kg, i.p.) 在年轻和年老小鼠中提高工作记忆[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 138117-50-7 |
| Formula | C15H13N5O4 |
| Molar Mass | 327.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9. [2]. Lahiri DK, et al. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann N Y Acad Sci. 2000 Apr;903:387-93. [3]. Glasky AJ, et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol Biochem Behav. 1994 Feb;47(2):325-9. |