| Bioactivity | Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1]. | ||||||||||||
| Target | IC50: 0.90 nM (N5), 1.83 nM (p09N1), 3.12 nM (p57N2) | ||||||||||||
| Invitro | Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution[1].Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir[1]. | ||||||||||||
| Name | Laninamivir | ||||||||||||
| CAS | 203120-17-6 | ||||||||||||
| Formula | C13H22N4O7 | ||||||||||||
| Molar Mass | 346.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249. |
Laninamivir
CAS: 203120-17-6 F: C13H22N4O7 W: 346.34
Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for
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