| Bioactivity | LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor[1]. |
| Invitro | LOE 908 hydrochloride 以浓度依赖方式阻断阳离子电导，IC50 为 560 nM。在电压钳位的 A7r5 细胞中，通过电压依赖的 Ca2+ 通道阻断二氢吡化物敏感的 Ba2+ 电流， IC50 为 28 μM[1]。 |
| In Vivo | LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride 可减轻大鼠急性神经运动功能障碍[2]。 Animal Model: |
| Name | LOE 908 hydrochloride |
| CAS | 143482-60-4 |
| Formula | C41H49ClN2O9 |
| Molar Mass | 749.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Krautwurst D, et al. The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 1994 Mar;349(3):301-7. [2]. Cheney JA, et al. The novel compound LOE 908 attenuates acute neuromotor dysfunction but not cognitive impairment or cortical tissue loss following traumatic brain injury in rats. J Neurotrauma. 2000 Jan;17(1):83-91. |