| Bioactivity | LJ001 is a broad-spectrum and orally active antiviral agent. LJ001 exerts antiviral activities by binding to viral membranes. LJ001 inhibits TGEV and PDCoV infection. LJ001 decreases TGEV N and PDCoV N-protein expression[1][2]. | ||||||||||||
| Invitro | LJ001 (0.782- 200 μM; 24 h) 没有显着的细胞毒性，对 ST 细胞的 CC50 值为 146.4 μM[1]。LJ001 (12.5 µM; 12, 24 h) 抑制传染性胃肠炎病毒 (TGEV) 和猪三角洲冠状病毒 (PDCoV) 感染[1]。LJ001 (12.5 µM; 1, 6,12, 24 h) 降低 ST 细胞中的 TGEV 和 PDCoV 基因 mRNA 表达[1]。LJ001 可以抑制一些包膜病毒的进入和传播，包括人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)、流感病毒、埃博拉病毒、沙粒病毒和痘病毒[1]。 Cell Viability Assay[1] Cell Line: | ||||||||||||
| In Vivo | LJ001 (20, 50 mg/kg; oral gavage or i.p.; daily for 7 days) 在小鼠中未显示出毒性[2]。 Animal Model: | ||||||||||||
| Name | LJ001 | ||||||||||||
| CAS | 851305-26-5 | ||||||||||||
| Formula | C17H13NO2S2 | ||||||||||||
| Molar Mass | 327.42 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Zhang Y, et al. Rhodanine derivative LJ001 inhibits TGEV and PDCoV replication in vitro. Virus Res. 2020 Nov;289:198167. [2]. Wolf MC, et al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62. |