| Bioactivity | LG190178 is a nonsteroidal vitamin D receptor (VDR) ligand that can induce the formation of VDR-retinoic acid X receptor (RXR) heterodimer complexes, stabilize the agonist conformation of the VDR ligand binding domain, and enable VDR to interact with coactivator proteins. LG190178 has the function of regulating calcium homeostasis, bone mineralization, and cell proliferation, differentiation, and apoptosis, and can be used in the study of psoriasis, osteoporosis, and cancer[1]. |
| CAS | 233268-81-0 |
| Formula | C28H42O5 |
| Molar Mass | 458.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Perakyla, et al. Gene regulatory potential of nonsteroidal vitamin D receptor ligands. Molecular endocrinology 19.8 (2005): 2060-2073. |