| Bioactivity | GEA 857 is a structural analog of the 5-hydroxytryptamine (5-HT) uptake blocker Alaproclate (HY-164011) that enhances responses evoked by muscarinic receptor agonists by inhibiting calcium-dependent potassium channels on certain membranes. This blockade can enhance or prolong muscarinic cholinergic effects. GEA 857 is used in the study of neurodegenerative diseases[1]. |
| CAS | 120493-42-7 |
| Formula | C15H22ClNO2 |
| Molar Mass | 283.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ögren, et al. GEA 857, A Putative Blocker of Potassium Conductance, Enhances Muscarinic Agonist‐Evoked Responses: Dissociation from an Action on 5‐HT Mechanisms. Pharmacology & toxicology 71.2 (1992): 112-119. |