| Bioactivity | LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity[1][2]. |
| Target | α4β1 integrin |
| Name | LDV-FITC |
| CAS | 1207610-07-8 |
| Sequence | {4-((N′-2-methylphenyl)ureido)-phenylacetyl}-Leu-Asp-Val-Pro-Ala-Ala-{Lys(FITC)} |
| Shortening | {4-((N′-2-methylphenyl)ureido)-phenylacetyl}-LDVPAA-{Lys(FITC)} |
| Formula | C69H81N11O17S |
| Molar Mass | 1368.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hyduk SJ, et al. Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants. Blood. 2007 Jan 1;109(1):176-84. [2]. Chigaev A, et al. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J Biol Chem. 2001 Dec 28;276(52):48670-8. |
LDV-FITC
CAS: 1207610-07-8 F: C69H81N11O17S W: 1368.51
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with
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