| Bioactivity | AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC50 of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling[1] |
| Target | PAR2 |
| Name | AY254 |
| CAS | 2093408-03-6 |
| Sequence | {5-Isoxazolylcarbonyl-Cha}-{Chg}-Ala-Arg-NH2 |
| Shortening | {5-Isoxazolylcarbonyl-Cha}-{Chg}-AR-NH2 |
| Formula | C30H49N9O6 |
| Molar Mass | 631.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. |